If the lengths are correct for the intent and if we are talking street - then there is no doubt that the 421 config is "better". In other words - if both a 41 and 421 are done well, 421 is "better" for street use and will deliver a broader spread of torque benefit. But - as far as I can see, neither is generally done well and the benefits people see tend to be in comparison to the stock system [there is a good stock manifold but there are a lot of very bad ones too]. People don't just change a header, they change the whole exhaust system and wow, the new one sounds really cool = power. And then of course, if you tune an exhaust to do particular things the you need a cam/carbs/porting/ignition all aligned with the same goals and many hours on the dyno. Most don't.
So, if you're a vendor, you keep a bunch of whatever is fashionable on the shelf and you make various claims about power gain secure in the knowledge that customers don't actually measure and just want something shiny with a cool noise.
If you are choosing from the readily available, then looking at the details is more important than the 41 or 421. Look at the flange the goes to the head - does it actually work with the inlet manifold? Look at how the pipes merge - can you imagine yourself as a pulse of gas flowing smoothly through them or are would you get violently banged around? Wall thickness, provision for hangers, flange to the rest of the system, O2 boss, finish etc.